Mar 08, 2020 bortezomib msds pdf bortezomib for injection. For maximum solubility in aqueous buffers, bortezomib should first be dissolved in dmso and then diluted with the aqueous buffer of choice. Targeted therapy is the result of about 100 years of research dedicated to understanding the differences between cancer cells and normal. A lintfree, plasticbacked disposable liner may be used in the biological. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Dailymed bortezomib injection, powder, lyophilized, for. Risk of serious damages to eyes 8 r to provide clients with more technology. Sc217785 bortezomib revision date 27jun2019 protect themselves and prevent spread of contamination. Dispose of in accordance with prevailing country, federal, state and local regulations. The above information is believed to be correct based on our present knowledge but does not purport to be complete.
Msds of bortezomib toxicity dangerous goods scribd. Velcade fact sheet last update 11282015 how velcade works. Identification of the substancepreparation and the companyundertaking supplier. Targeted therapy is the result of about 100 years of research dedicated to understanding the differences between cancer cells and normal cells. Product and company identification product name bortezomib. Bortezomib is a novel synthetic dipeptide boronic acid with a high specificity for the 26s proteasome and a firstinclass proteasome inhibitor with antitumor activity. Keep container tightly closed precautionary statements disposal. Bortezomib is the first proteasome inhibitor to be approved by the us fda for multiple myeloma, a blood cancer.
Velcade bortezomib for injection prescribing information. The above information is believed to be correct based on our present knowledge but does not purport to be. Chemicalbook provide chemical industry users with bortezomib boiling point melting point,bortezomib density msds formula use,if you also need to. Material safety data sheet of bortezomib abmole bioscience. Bortezomib is an important agent in multiple myeloma treatment, but resistance in cell lines and patients has been described. Risk of serious damages to eyes 8 r to provide clients with more technology support, we will present efficient regulatory documents to show professional abilities in this field. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Formerly known as material safety data sheets, phac now refers to them as pathogen safety data sheets or psdss. Bortezomib is a reversible inhibitor of the chymotrypsin like activity of the 26s proteasome in mammalian cells. Ghobrial im, hong f, padmanabhan s, et al, phase ii trial of weekly bortezomib in. Palumbo a, bringhen s, rossi d, et al, bortezomib, melphalan, prednisone and thalidomide vmpt followed by maintenance with bortezomib and thalidomide for initial treatment of elderly multiple. Bortezomib is associated with a low rate of serum enzyme elevations during treatment and to rare instances of clinically apparent, acute liver injury. What bortezomib powder for solution for injection looks like and contents of the pack bortezomib powder for solution for injection is a white to offwhite cake or powder. The main mechanisms of resistance described in cancer fall into one of.
It is a dipeptidyl boronic acid that reversibly inhibits the 26s proteasome. During all fire fighting activities, wear appropriate protective equipment, including self. Bortezomib powder for solution for injection is a white to offwhite cake or powder. You agree that the information as provided here through an intermediary may not be error free. The results observed in a large randomized trial apex comparing bortezomib and highdose dexamethasone demonstrated a significant benefit for bortezomib in terms of response rate, progression free and overall survival. Bortezomib, sold under the brand name velcade among others, is an anticancer medication used to treat multiple myeloma and mantle cell lymphoma. Hazards identification classification of the substance or mixture ghs classification in accordance with 29 cfr 1910 osha hcs skin irritation category 2, h315 serious eye damage category 1, h318. Bortezomib originally codenamed ps341 is the first therapeutic proteasome inhibitor to the tested in humans. Velcade bortezomib side effects, images, uses, dosage. A reversible inhibitor of the 26s proteasomea barrelshaped multiprotein particle found in the. Only select registry of toxic effects of chemical substances rtecs data is presented here. This chemical, bortezomib cas 179324697, is sparingly soluble in aqueous buffers. Dosing may continue for 2 more cycles for a total of 8 cycles if response is first seen at cycle 6.
Identification of the substancemixture and of the companyundertaking product name. Sc217785 bortezomib revision date 27jun2019 precautionary statements storage store locked up store in a wellventilated place. These results led to bortezomib being approved for use in relapsed andor refractory myeloma patients. The following bortezomib msds detailed information are provided by nanjing aily biotechnology co. Bortezomib is a proteasome inhibitor and antineoplastic agent that is used in treatment of refractory multiple myeloma and certain lymphomas. Velcade is supplied as a lyophilized powder in singledose vials containing 3. This product information was approved at the time this auspar was published. Product and company identification product name bortezomib product number 2204 identified uses for research use only ruo. Bortezomib definition of bortezomib by medical dictionary. Material safety data sheet of bortezomib contains identification of substance and details of the supplier of the safety data sheet. Indication of any immediate medical attention and special treatment needed note to physicians treat symptomatically.
Product information for auspar velcade bortezomib janssen cilag pty ltd pm20110085434 final 16 january 20. Bortezomib interferes with the growth of some cancer cells and keeps them from spreading in your body. Page 1 material safety data sheet date of preparation. Dexamethasone msds search our sds online database free. It has a role as an antineoplastic agent, a proteasome inhibitor, a protease inhibitor and an antiprotozoal drug. Bortezomib caused comparable growth suppression in lncappro5 and pc3mpro4 cells with an ic90 of 10 nm. Synthesis and characterization of organic impurities in. Bortezomib velcade is a highly selective, reversible inhibitor of the 26s proteasome with a ki value of 6nm, which has shown high antimyeloma activity. Free msds or sds search site millions of free msds sheets. You should not receive velcade if you are allergic to bortezomib, boron, or mannitol. During formulation, in which mannitol is used, a bortezomibmannitol adduct is formed during lyophilization, which converts to the monomeric form upon reconstitution.
Velcade product information name of the medicine bortezomib bortezomib. Any unused product or waste material should be disposed of in accordance with local requirements. Bortezomib reversibly inhibits the 26s proteasome, a large protease complex that degrades ubiquinated proteins. Analysis of two commercially available bortezomib products. Velcade bortezomib is approved for the treatment of adults with multiple myeloma a cancer of the plasma cells. Highlights of prescribing information these highlights do not include all the information needed to use velcade safely and effectively. Thalidomide vmpt followed by maintenance with bortezomib and thalidomide for initial treatment of elderly multiple myeloma patients, blood, 2009, 11422.
Jun 07, 2019 what other drugs will affect bortezomib velcade. Most important symptoms and effects, both acute and delayed symptoms no information available. Aug, 2019 bortezomib msds pdf bortezomib for injection. Nov 22, 2019 at a prespecified interim analysis with median followup of 16.
In the past, cancer treatment has focused primarily on killing rapidly dividing cells because that is an important feature of cancer cells. Bortezomib c19h25bn4o4 cid 387447 structure, chemical names, physical. By blocking the targeted proteolysis normally performed by the proteasome, bortezomib. Apr 01, 2011 this equilibrium means that drug products containing bortezomib are unique and chemically complex. Bortezomib drug substance exists in boronic anhydride trimeric form au pdf ausparausparbortezomib116pi.
A profile of impurities in bortezomib anhydride, produced by a recently developed convergent technology, has been characterized. Bortezomib 1mg powder for solution for injection is for intravenous use only. Hplcms analysis of the drug essence revealed three impurities. A reversible inhibitor of the 26s proteasomea barrelshaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Bortezomib cas 179324697 scbt santa cruz biotechnology. Bortezomib oel fastrac with ade affygility solutions. Exclusive csoa free msds or sds sheets custom search engine and siri databases will find your msdssds sheet at no cost guaranteed these easy to search databases and tools includes all. Safety and efficacy of subcutaneous formulation of bortezomib. Velcade is also approved for the treatment of adults with mantle cell lymphoma a cancer of the lymph nodes. Bortezomib is lphenylalaninamide substituted at the amide nitrogen by a 1dihydroxyboranyl3methylbutyl group and at nalpha by a pyrazin2ylcarbonyl group.
Bortezomib velcade cas 179324697 abmole bioscience. This includes multiple myeloma in those who have and have not previously received treatment. To provide clients with more technology support, we will present efficient regulatory documents to show professional abilities in this field. Reversibly inhibits chymotrypsinlike activity at 26s proteasome, leading to activation of signaling cascades, cellcycle. Bortezomib d5 safety data sheet according to regulation ec no. Antineoplastic pregnancy risk category d action inhibits proteasomes enzyme complexes that regulate protein homeostasis within cells. Jan 31, 2020 bortezomib msds pdf bortezomib for injection. Bortezomib is used to treat multiple myeloma and mantle cell lymphoma.